What is the difference between high pressure homogenizer and normal homogenizer?

1. What is high pressure homogenizer?

A high-pressure homogenizer, also known as a “high-pressure fluid nano-homogenizer,” can allow suspended materials to flow at high speed through a special internal structure chamber (high-pressure homogenizer chamber) under ultra-high pressure (up to 60000 psi), causing a series of physical, chemical, structural and other changes in the material, ultimately achieving homogenization.

2. What is the working principle of high speed Homogenizer?

Its working principle is mainly achieved through the following key steps:

(1) Generation of high-pressure fluid: The high-pressure homogenizer injects the sample into the high-pressure chamber through a pump. The pump will apply high pressure, causing the sample to pass through the narrow slit of the homogenization valve, forming a high-speed flowing high-pressure fluid.

(2) The function of homogenization valve: The homogenization valve is a key component of a high-pressure homogenizer. It consists of a pair of symmetrical slits, forming a narrow channel. When a high-speed fluid passes through a homogenization valve, the fluid is limited by a narrow slit, resulting in high-speed shear and impact forces.

(3) The effect of shear and impact: When high-pressure fluid passes through the narrow slit of the homogenization valve, strong shear and impact occur between fluid molecules, leading to collision and friction between sample molecules and particles.

(4) Dispersion and homogenization effects: Shear and impact forces break, disperse, and homogenize particles, cells, or colloids in the sample, thereby achieving particle size reduction, uniform dispersion, and improved stability of the sample.

 

3. What is the purpose of a high pressure homogenizer?

High pressure homogenizers are applied in multiple fields, as follows:

(1) Biomedical field: High pressure homogenizers can be used for cell fragmentation, protein separation and purification, gene extraction, and other aspects, and have important applications in biomedical research.

(2) Food industry: High pressure homogenizers can be used for emulsifying and stabilizing dairy products, fruit juices, beverages, etc., making products more delicate and with a better taste.

(3) Chemical industry: High pressure homogenizers can be used for the preparation of nanomaterials, production of coatings and pigments, and play an important role in improving product quality and performance.

(4) Environmental science: High pressure homogenizers can be used to treat environmental pollutants such as wastewater and exhaust gas, dispersing, mixing, and decomposing them, thereby reducing environmental pollution.

(5) Pharmaceutical industry: High pressure homogenizers can be used to prepare fat particles, microemulsions, liposomes, suspensions, and microcapsules, etc; Cell fragmentation, extraction and homogenization of intracellular and extracellular substances in bioengineering products.

(6) Cosmetics, fine chemicals and other industries: homogeneous dispersion of products.

 

4. What are the advantages of a high pressure homogenizer?

(1) Efficient homogenization: It can efficiently homogenize samples with good homogenization effect, which can achieve the smallest particle size of the sample, improve the uniformity and stability of liquid mixing.

(2) Multifunctionality: In addition to sample homogenization, it can also be used for sample centrifugation, fragmentation, tumor cell fragmentation, etc.

(3) Easy to operate: Compared to other experimental equipment, the use of high-pressure homogenizers is very simple. Simply place the sample that needs to be homogenized into the sample tube and press the start button to quickly complete the homogenization operation.

(4) No solvent needs to be added: When using a high-pressure homogenizer for sample homogenization, no solvent needs to be added to reduce environmental pollution and the impact on experimental results.

(5) High precision: It can precisely control the homogenization process of the sample by adjusting the rotation speed and the pressure of the working head, thereby ensuring the accuracy of homogenization.

 

5. What is a disadvantage of high pressure Homogenizer?

(1) High pressure homogenizers require high pressure when processing materials, which may lead to severe equipment wear and increase maintenance costs.

(2) High pressure homogenizers may have the problem of low output during continuous production, as their processing capacity is usually small.

(3) The high-pressure homogenizer has poor performance in handling high viscosity materials.

(4) High price

(5) Large volume

(6) Heavy weight

It should be noted that the above drawbacks may vary depending on the specific model and usage conditions of the high-pressure homogenizer. When using a high-pressure homogenizer, its advantages and disadvantages should be fully considered to determine whether it is suitable for specific applications.

 

6. What is the difference between high pressure homogenizer and normal homogenizer?

There are significant differences in the working principle, application, and efficiency between high-pressure homogenizers and ordinary homogenizers.

(1) Working principle:

• A normalhomogenizer is a device that uses shear and impact forces to crush samples and ultimately achieve sample dispersion and homogenization. The homogenizer uses high-speed rotating gears and rotors to evenly and quickly dry and wet grind materials, with the aim of achieving particle size damage and achieving uniform emulsification, dispersion, and mixing of uneven materials.
• The high-pressure homogenizer utilizes a high-speed rotating rotor to generate strong shear and impact forces, causing the material flow of solid, liquid, and gas three-phase mixture to undergo shear and compression forces in a specific annular groove, and then split, break, shear, and break, achieving the effect of emulsification, dispersion, mixing, and uniformity. It can be understood that high-pressure homogenizers are more efficient than homogenizers, because high-pressure homogenizers generate strong impact forces through high pressure, making sample dispersion more uniform.

(2) Application:

• The high-pressure homogenizer is operated through hydraulic control, making the use process more convenient, and the entire process of pressurization and pressure relief is relatively easy. This can break through the limitations of traditional manual pressurization, reduce working pressure in work, and solve the problem of excessive workload. The operation is very convenient, as long as the switch knob is turned, the pressure adjustment work can be completed, ensuring long-term stable and efficient operation in various environmental fields.
• High pressure homogenizers are divided into ordinary homogenizers and low-speed homogenizers based on the reciprocating frequency of the plunger per minute. When the material, processing accuracy, and structure are the same, the lower the rotational speed within a certain range, the greater the wear of each friction pair (such as shaft and bearing, plunger and seal, etc.) per unit time, as well as the degree of damage to various stressed parts in the pump body (such as valve core, valve seat, etc.) within the same time, and the stability of equipment operation is also greatly improved. So this series is particularly suitable for long-term use.
• High pressure homogenizers can be divided into manual control, manual hydraulic control, and automatic hydraulic control according to their control methods. Currently, manual control is dominant in the market. If the entire production line is automatically controlled, a fully automatic homogenizer can be selected.
• High pressure homogenizers can be divided into upstream homogenizers and downstream homogenizers based on their position on the production line. The homogenizer commonly used before sterilization is called an upstream homogenizer, and the homogenizer used after sterilization is called a downstream homogenizer. The former usually uses a regular homogenizer, while the latter requires a sterile homogenizer.

(3) Efficiency:

The efficiency of high-pressure homogenizers is usually higher than that of ordinary homogenizers. This is because the high-pressure homogenizer can generate strong impact force through high pressure, making the sample dispersion more uniform. This efficient working principle makes high-pressure homogenizers have outstanding performance and high stability in practical applications.